What sources determine the implication of a resistance gene?

Arkstone relies on published, publicly available evidence so that resistance-gene interpretation can be reviewed rather than taken on trust.

Which sources are used?

• Peer-reviewed articles and studies
• Published clinical guidelines that address how resistance-gene results should be interpreted
• Open-source resistance-gene databases
• Public antimicrobial-resistance data published by the National Institutes of Health

All of these sources are publicly accessible, so the reasoning behind an interpretation can be checked independently.

Can I see the evidence behind a specific finding?

Yes. In OneChoice Plus, selecting a resistance finding opens its details, including a description of the resistance class, the drugs affected, and links to primary sources and articles.

What does hovering over a resistance icon show?

In the MedsMatrix, hovering over a resistance icon identifies the resistance class involved, along with any drug-specific note that applies.

When public NIH isolate data is available for that resistance class and organism, the tooltip also shows how frequently those genes have been detected — for example, the share of tested isolates of that organism in which they were found. This gives useful epidemiologic context for judging how commonly a resistance mechanism occurs.

That figure reflects the resistance class rather than a single gene, and it appears only when matching public data exists, so it will not be shown for every resistance class or organism.

The intent is to make the underlying evidence visible so clinicians can form their own conclusions. If published data about a particular resistance gene or organism is limited, see What if there is not much published data about a resistance gene or organism?